Nattokinase is a proteolytic enzyme originally identified in natto, a traditional Japanese food made from fermented soybeans. Nattokinase is measured by its enzymatic activity in Fibrinolytic Units (FU) and has been studied in human research for its effects on cardiovascular and circulatory measures. Sources: Sumi et al., Experientia (1987); Hsia et al., Scientific Reports (2022).

FU stands for Fibrinolytic Units, a standardized measure of nattokinase enzyme activity. It reflects the enzyme’s ability to break down fibrin under standardized testing conditions. Higher FU indicates greater measured enzymatic activity—not simply a greater weight of nattokinase. For example, 13,500 FU indicates 13,500 units of measured nattokinase activity.

Why use Acid-Resistant Capsules?

Nattokinase is a protein enzyme that may be affected by the acidic environment of the stomach. Acid-resistant capsules are designed to delay capsule opening until after passage through the stomach, helping protect the enzyme during gastric transit and deliver it to the intestinal environment.

When should I take it?

Nattokinase is commonly taken between meals or on an empty stomach, such as 30–60 minutes before a meal or at least 2 hours after eating. Taking nattokinase away from meals is commonly recommended when it is being used for systemic enzyme support rather than as a digestive enzyme.

Who Should Not Take It?

Individuals taking anticoagulant or antiplatelet medications, those with bleeding disorders, or anyone with an increased risk of bleeding should consult a healthcare professional before using nattokinase. If you are scheduled for surgery or an invasive procedure, discuss nattokinase use with your healthcare professional beforehand.

13,500 FU Nattokinase for Cardiovascular & Circulatory Support

High-activity nattokinase in one acid-resistant capsule—designed around measured enzyme activity, purposeful delivery, and human research.

PB Natto 13,500 FU acid-resistant capsule specification badge

PBE Nattokinase 13,500 FU acid-resistant capsule bottle

WHAT HAS HUMAN RESEARCH STUDIED?

Chen et al. 2022 nattokinase study snapshot

Nattokinase dose outcome chart — 10,800 FU vs 3,600 FU

Published Research:
Chen H, Chen J, Zhang F, et al. Effective management of atherosclerosis progress and hyperlipidemia with nattokinase: A clinical study with 1,062 participants. Front Cardiovasc Med. 2022;9:964977.

View the study on PubMed

Why PBE Natto is Different

FAQ

Nattokinase is a proteolytic enzyme originally identified in natto, a traditional Japanese food made from fermented soybeans. Nattokinase is measured by its enzymatic activity in Fibrinolytic Units (FU) and has been studied in human research for its effects on cardiovascular and circulatory measures.
Sources: Sumi et al., Experientia (1987); Hsia et al., Scientific Reports (2022).
FU stands for Fibrinolytic Units, a standardized measure of nattokinase enzyme activity. It reflects the enzyme’s ability to break down fibrin under standardized testing conditions. Higher FU indicates greater measured enzymatic activity—not simply a greater weight of nattokinase.
For example, 13,500 FU indicates 13,500 units of measured nattokinase activity.
Nattokinase is a protein enzyme that may be affected by the acidic environment of the stomach.
Acid-resistant capsules are designed to delay capsule opening until after passage through the stomach, helping protect the enzyme during gastric transit and deliver it to the intestinal environment.
Nattokinase is commonly taken between meals or on an empty stomach, such as:
- 30–60 minutes before a meal, or
- At least 2 hours after eating.
Taking nattokinase away from meals is commonly recommended when it is being used for systemic enzyme support rather than as a digestive enzyme.
Individuals taking anticoagulant or antiplatelet medications, those with bleeding disorders, or anyone with an increased risk of bleeding should consult a healthcare professional before using nattokinase.
If you are scheduled for surgery or an invasive procedure, discuss nattokinase use with your healthcare professional beforehand.