Want to explore the research? Read the human clinical research behind nattokinase.
NATTOKINASE IN HUMAN RESEARCH
10,800 FU/day | 1,062 participants | 12 months
Human research has evaluated nattokinase at 10,800 FU per day for 12 months in 1,062 participants. Researchers reported changes in several cardiovascular-related measures, including lipid measures and carotid measurements.
Learn more about nattokinase, FU activity, acid-resistant delivery, and the human research behind it.
Important context: This was a retrospective clinical study, not a randomized placebo-controlled trial. The PBE Natto product was not used in this study, and the findings should not be interpreted as demonstrating that PBE Natto produces the same outcomes.
Published Research:
Chen H, Chen J, Zhang F, et al. Effective management of atherosclerosis progress and hyperlipidemia with nattokinase: A clinical study with 1,062 participants. Front Cardiovasc Med. 2022;9:964977.
WHY FU MATTERS
FU Measures Activity — Not Simply Ingredient Weight
Nattokinase supplements are commonly described in milligrams, but milligrams tell you the weight of the ingredient—not its measured enzymatic activity.
Fibrinolytic Units (FU) measure nattokinase enzyme activity. For that reason, FU provides a more meaningful way to understand the activity of a nattokinase formulation and to compare the amounts used in published research.
10,800 FU/day
Amount evaluated in the 2022 retrospective clinical study
13,500 FU/capsule
Activity provided by PBE Natto
60 capsules
One acid-resistant capsule per serving
Important distinction: The 10,800 FU/day figure describes the amount evaluated in the cited 2022 study. PBE provides 13,500 FU per capsule, but the PBE product itself was not evaluated in that study. A higher FU value should not be interpreted as evidence of proportionally greater clinical benefit.
WHY ACID-RESISTANT DELIVERY MATTERS
Enzyme Activity Is Only Useful If the Formulation Is Designed With Delivery in Mind
PB Natto is supplied in an acid-resistant vegetarian capsule, rather than a conventional immediate-release capsule.
The capsule is manufactured from plant-derived HPMC (hydroxypropyl methylcellulose) and hypromellose phthalate and is specifically designed as an acid-resistant/enteric capsule.
For an enzyme-based supplement such as nattokinase, PBE considers both measured enzyme activity (FU) and delivery format when designing the finished product.
13,500 FU
Measured nattokinase activity per capsule
Acid-Resistant Capsule
Enteric capsule technology rather than conventional immediate-release delivery
One Capsule
13,500 FU provided in a single-capsule serving
WHY PB NATTO?
Designed Around Activity, Delivery, and the Human Research
PB Natto was formulated for people looking beyond conventional low-activity nattokinase supplements.
Published human research has evaluated 10,800 FU per day for 12 months in 1,062 participants. PBE provides 13,500 FU of measured nattokinase activity in one acid-resistant capsule.
The PBE formulation brings together three deliberate product characteristics:
13,500 FU Per Capsule
High measured nattokinase enzyme activity in a single-capsule serving.
Acid-Resistant Delivery
An acid-resistant vegetarian capsule selected as part of PBE's enzyme-focused formulation strategy.
Simple Formulation
Nattokinase delivered without building an unnecessary multi-ingredient cardiovascular formula around it.
Built for the research-informed consumer.
PBE focuses on measured enzyme activity, purposeful formulation, and transparent scientific context—not simply milligrams on a label.
READY TO CHOOSE A RESEARCH-INFORMED NATTO?
13,500 FU. One Acid-Resistant Capsule.
PB Natto provides 13,500 FU of measured nattokinase activity per capsule in an acid-resistant vegetarian delivery system.
60 capsules | 60 servings | $90
13,500 FU PB Natto
Per Acid-Resistant Capsule
High-potency nattokinase formulated to support cardiovascular health and healthy circulation.
• Supports healthy blood flow
• Supports natural fibrinolytic activity
• 13,500 FU of nattokinase activity per capsule
• Acid-resistant capsuleWho should not take this: Individuals taking anticoagulant or antiplatelet medications, those with bleeding disorders, or anyone with an increased risk of bleeding should consult a healthcare professional before use. If scheduled for surgery or an invasive procedure, discuss use with your healthcare professional beforehand.